Cerebral microdialysis in patients with fulminant hepatic failure

Glyphosate Poisoning with Acute Fulminant Hepatic Failure

Background: Glyphosate containing herbicides are widely used the world over. They are marketed as nontoxic to humans, but numerous studies have showed that these glyphosate-based herbicides (GlySH) can cause multiorgan damage.1 Recent reports of animal studies on rats have raised a doubt of liver damage after long term exposure to GlySH. Case Presentation: a young male had chronic exposure to G...

Pathophysiology of cerebral edema in fulminant hepatic failure.

F hepatic failure (FHF) is a devastating disease and is still associated with a high mortality (1). FHF results in progressive multi-organ failure with a dramatic impact on the brain. Indeed, development of intracranial hypertension (IH) is a leading cause of death in FHF. During this decade two theories have independently emerged to explain the pathogenesis of cerebral edema and intrac...

Fulminant hepatic failure due to metastatic choroidal melanoma

The effect of hyperventilation upon cerebral blood flow and metabolism in patients with fulminant hepatic failure.

Patients with FHF have a high risk of cerebral edema and intracranial hypertension. The pathophysiological background for this phenomenon is not completely settled, but alteration in CBF as well as cerebral metabolism seems to be of importance. Mechanical hyperventilation has a prompt effect on intracranial pressure. This effect is assumed to be caused by the hypocapnia induced alkalosis which ...

Circulating immune complexes in patients with fulminant hepatic failure.

Circulating immune complexes were found in 15 of 16 patients with fulminant hepatic failure due to viral hepatitis and all of six patients who had had halothane anaesthesia; however, they were found in only five of 32 patients with paracetamol-induced hepatic necrosis. The levels of circulating immune complexes were not related to the severity of the clinical course, development of renal failur...